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A CRISPR-based method to alter the expression of any mammalian gene and assay the functional consequences has arrived.

Two papers published in this issue report on the third and final phase of The 1000 Genomes Project. Begun in 2008, the project has developed an open resource that now includes the genomic data for more than 2,500 individuals from 26 global populations. The main report from the consortium describes key features of all 88 million genetic variants identified, while an extended analysis provides a more detailed account of larger and more complex variants. Cover: Cahier Archive/Corbis

NMDA sensitization via organic solvents in multiple chemical sensitivity (MCS)