Researchers at the University of Toronto have uncovered new insights on the genetic causes of Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease. These findings could uncover a new way to detect a genetic predisposition to ALS before the disease strikes. The team state that a common mutation associated with ALS is an unstable repeated DNA sequence within the C9orf72 gene that could reach into the thousands. However, it is unknown how many repeats would be sufficient to…
Researchers discover new molecule responsible for ovarian cancer proliferation and drug resistance.
Acute liver failure is a rare yet life-threatening disease for young children. It often occurs extremely rapidly, for example, when a child has a fever. Yet in around 50 percent of cases it is unclear as to why this happens. Now, a team of researchers working on an international research project headed by Technische Universität München (TUM), the Helmholtz Zentrum Munich and Heidelberg University Hospital have discovered a link between the disease and mutations in a specific gene. The…
Zika virus may persist in eyes: Disease may spread from infected eyes
virus is capable of infecting the eye, according to a new study. The study, in mice, helps explain why some people with Zika virus develop eye disease, and suggests that contact with infected eyes may play a role in spreading the disease.
Researchers map epigenetic autism pathway during neurodevelopment.
By uncovering the mechanism by which fibrous tissue cells in the lung multiply, researchers at The Children's Hospital Los Angeles (CHLA), Keck School of Medicine, Nanjing Drum Tower Hospital, Instituto Nacional de Enfermedades Respiratorias, and McMaster University have identified a promising new approach for the treatment of pulmonary fibrosis. Idiopathic pulmonary fibrosis or IPF, where the disease appears spontaneously and without a known cause, is a severe, chronic lung disease in which…
Study identifies a previously unknown mechanism of neurofibrillary tangle formation.
Now, a new study from researchers at Sanford Burnham takes a step forward in understanding how similar, yet genetically unrelated neurodegenerative diseases, such as Alzheimer’s disease, frontal temporal dementia, and PSP are caused by the protein tau. The team states that their new study creates new opportunities to target this key protein that leads to the brain lesions found in patients with impaired motor functions and dementia. The opensource study is published in the journal Neuron.
Researchers begin to map inherited gene mutations in colorectal cancer.
In a group of patients diagnosed with colorectal cancer at 40 or younger, 1.3 percent of the patients carried germline TP53 gene mutations, although none of the patients met the clinical criteria for an inherited cancer syndrome associated with higher lifetime risks of multiple cancers, according to a study published by JAMA Oncology.
Epigenetic mutation which shortens telomeres linked to greater emphysema risk in smokers.
Mutations linked to repair of chromosome ends may make emphysema more likely in smokers - healthinnovations
Researchers map epigenetic pathways linked to cystic fibrosis disease severity.
Mutation of one gene is all it takes to get cystic fibrosis (CF), but disease severity depends on many other genes and proteins. For the first time, researchers at the UNC School of Medicine have identified genetic pathways, or clusters of genes, that play major roles in why one person with CF might never experience the worse kinds of symptoms while another person will battle severe airway infection for a lifetime. The finding opens avenues of research toward new precision medicine…
Researchers discover new molecular-based immune response which protects lungs during severe infections.
Blood Vessels, Genetics, Lungs, Lunges
Precision medicine developed to protect against intellectual disability during neurodevelopment.