Researchers at the University of Toronto have uncovered new insights on the genetic causes of Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease. These findings could uncover a new way to detect a genetic predisposition to ALS before the disease strikes.  The team state that a common mutation associated with ALS is an unstable repeated DNA sequence within the C9orf72 gene that could reach into the thousands. However, it is unknown how many repeats would be sufficient to…

Researchers at the University of Toronto have uncovered new insights on the genetic causes of Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease. These findings could uncover a new way to detect a genetic predisposition to ALS before the disease strikes. The team state that a common mutation associated with ALS is an unstable repeated DNA sequence within the C9orf72 gene that could reach into the thousands. However, it is unknown how many repeats would be sufficient to…

A team of researchers have made a significant discovery in the mechanism of brain swelling, paving the way to preventative treatment for severe to fatal brain damage following stroke, head injury or cardiac arrest. The team state the their new study research paves the way for a preventative drug treatment for severe brain damage following stroke, infection, head injury or cardiac arrest. By turning off a single gene, scientists from the Djavad Mowafaghian Centre for Brain Health (DMCBH) were…

Researchers stop brain swelling at the source in animal model.

A team of researchers have made a significant discovery in the mechanism of brain swelling, paving the way to preventative treatment for severe to fatal brain damage following stroke, head injury or cardiac arrest. The team state the their new study research paves the way for a preventative drug treatment for severe brain damage following stroke, infection, head injury or cardiac arrest. By turning off a single gene, scientists from the Djavad Mowafaghian Centre for Brain Health (DMCBH) were…

Now, a new study from researchers at Sanford Burnham takes a step forward in understanding how similar, yet genetically unrelated neurodegenerative diseases, such as Alzheimer’s disease, frontal temporal dementia, and PSP are caused by the protein tau. The team states that their new study creates new opportunities to target this key protein that leads to the brain lesions found in patients with impaired motor functions and dementia.  The opensource study is published in the journal Neuron.

Study identifies a previously unknown mechanism of neurofibrillary tangle formation.

Now, a new study from researchers at Sanford Burnham takes a step forward in understanding how similar, yet genetically unrelated neurodegenerative diseases, such as Alzheimer’s disease, frontal temporal dementia, and PSP are caused by the protein tau. The team states that their new study creates new opportunities to target this key protein that leads to the brain lesions found in patients with impaired motor functions and dementia. The opensource study is published in the journal Neuron.

yet of what causes schizophrenia, a condition that affects around 1% of the global population. The team states that their work presents strong evidence that disruption of a delicate chemical balance in the brain is heavily implicated in the disorder. In the largest ever study of its kind, the team found that disease-linked mutations disrupt specific sets of genes contributing to excitatory and inhibitory signalling, the balance of which plays a crucial role in healthy brain development and…

Researchers provide strongest evidence yet of neurogenetic cause of Schizophrenia.

yet of what causes schizophrenia, a condition that affects around 1% of the global population. The team states that their work presents strong evidence that disruption of a delicate chemical balance in the brain is heavily implicated in the disorder. In the largest ever study of its kind, the team found that disease-linked mutations disrupt specific sets of genes contributing to excitatory and inhibitory signalling, the balance of which plays a crucial role in healthy brain development and…

In a study involving more than 31,000 women with cancer-causing mutations in the BRCA1 or BRCA2 genes, researchers at The Basser Center for BRCA, the Abramson Cancer Center, and the University of Pennsylvania identified mutations that are associated with significantly different risks of breast and ovarian cancers. The researchers state the results, which show that some mutations confer higher risks of breast cancer, while other mutations show higher risks of ovarian cancer, may lead to more…

Large-scale study shows risk of breast and ovarian cancer differs by type of BRCA1, BRCA2 mutation.

In a study involving more than 31,000 women with cancer-causing mutations in the BRCA1 or BRCA2 genes, researchers at The Basser Center for BRCA, the Abramson Cancer Center, and the University of Pennsylvania identified mutations that are associated with significantly different risks of breast and ovarian cancers. The researchers state the results, which show that some mutations confer higher risks of breast cancer, while other mutations show higher risks of ovarian cancer, may lead to more…

Despite the abuse potential of opioid drugs, they have long been the best option for patients suffering from severe pain. The drugs interact with receptors on brain cells to tamp down the body’s pain response. But now, neuroscientists at Washington University have found a way to activate opioid receptors with light.  In a test tube, the scientists melded the light-sensing protein rhodopsin to key parts of opioid receptors to activate receptor pathways using light. They also influenced the…

Researchers successfully implant and control light-sensitive opioid receptors in mice via optogenetics.

Despite the abuse potential of opioid drugs, they have long been the best option for patients suffering from severe pain. The drugs interact with receptors on brain cells to tamp down the body’s pain response. But now, neuroscientists at Washington University have found a way to activate opioid receptors with light. In a test tube, the scientists melded the light-sensing protein rhodopsin to key parts of opioid receptors to activate receptor pathways using light. They also influenced the…

Researchers from the UC San Diego and the University of Iowa have identified a key piece in the complex molecular puzzle underlying heart failure, a serious and sometimes life-threatening disorder affecting more than 5 million Americans. In an opensource study published in Cell Reports, the team explores the heart’s progression from initial weakening to heart failure, and found that a protein, known as RBFox2, plays a critical role in this process.

Researchers identify protein responsible for epigenetic change in heart failure.

Researchers from the UC San Diego and the University of Iowa have identified a key piece in the complex molecular puzzle underlying heart failure, a serious and sometimes life-threatening disorder affecting more than 5 million Americans. In an opensource study published in Cell Reports, the team explores the heart’s progression from initial weakening to heart failure, and found that a protein, known as RBFox2, plays a critical role in this process.

Researchers at the University of California, San Diego have found that the three-dimensional shape of the cerebral cortex, the wrinkled outer layer of the brain controlling many functions of thinking and sensation, strongly correlates with ancestral background. The team state that the findings open the door to more precise studies of brain anatomy going forward and could eventually lead to more precision medicine approaches for diagnosing and treating brain diseases.  They go on to add that…

First large-scale study finds topography of cerebral cortex differs with ancestral genetics.

Researchers at the University of California, San Diego have found that the three-dimensional shape of the cerebral cortex, the wrinkled outer layer of the brain controlling many functions of thinking and sensation, strongly correlates with ancestral background. The team state that the findings open the door to more precise studies of brain anatomy going forward and could eventually lead to more precision medicine approaches for diagnosing and treating brain diseases. They go on to add that…

UNC researchers create DNA repair map of the entire human genome

UNC researchers create DNA repair map of the entire human genome

UNC researchers create DNA repair map of the entire human genome Repinned by @drbrunogallo

Now, Whitehead Institute researchers have developed a methodology to monitor changes in DNA methylation in real-time in single cells.  The team state that their tool will allow the global medical community to look in a very detailed way at issues like imprinting during development and screening for the activation of genes silenced in diseases like cancer, highlighting which drug will activate a given gene.  The opensource study is published in the journal Cell.

Single-cell imaging developed which can record DNA methylation in real time.

Now, Whitehead Institute researchers have developed a methodology to monitor changes in DNA methylation in real-time in single cells. The team state that their tool will allow the global medical community to look in a very detailed way at issues like imprinting during development and screening for the activation of genes silenced in diseases like cancer, highlighting which drug will activate a given gene. The opensource study is published in the journal Cell.

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