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Researchers at the University of Toronto have uncovered new insights on the genetic causes of Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease. These findings could uncover a new way to detect a genetic predisposition to ALS before the disease strikes.  The team state that a common mutation associated with ALS is an unstable repeated DNA sequence within the C9orf72 gene that could reach into the thousands. However, it is unknown how many repeats would be sufficient to…

Human generational study pinpoints epigenetic cause of Amyotrophic Lateral Sclerosis (ALS).

Researchers at the University of Toronto have uncovered new insights on the genetic causes of Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease. These findings could uncover a new way to detect a genetic predisposition to ALS before the disease strikes. The team state that a common mutation associated with ALS is an unstable repeated DNA sequence within the C9orf72 gene that could reach into the thousands. However, it is unknown how many repeats would be sufficient to…

Thousands of women are living with ovarian cancer in Canada. It is estimated that this year, 2,800 Canadian women will be newly diagnosed with this disease. Even though ovarian cancer continues to be one of the most serious women’s cancers, there is a real lack in reliable early detection tests and few treatment options.  Now, researchers at Lawson Health Research Institute have uncovered an important new target for ovarian cancer therapy. Contrary to previous research this new study found…

Researchers discover new molecule responsible for ovarian cancer proliferation and drug resistance.

In a study involving more than 31,000 women with cancer-causing mutations in the BRCA1 or BRCA2 genes, researchers at The Basser Center for BRCA, the Abramson Cancer Center, and the University of Pennsylvania identified mutations that are associated with significantly different risks of breast and ovarian cancers. The researchers state the results, which show that some mutations confer higher risks of breast cancer, while other mutations show higher risks of ovarian cancer, may lead to more…

Large-scale study shows risk of breast and ovarian cancer differs by type of BRCA1, BRCA2 mutation.

Large-scale study shows risk of breast and ovarian cancer differs by type of mutation.

Chemists show that ALS is a protein aggregation disease - neuroinnovations

Cornell scientists show that ALS is a protein aggregation disease.

Scientists link ALS progression to increased protein instability.

Acute liver failure is a rare yet life-threatening disease for young children. It often occurs extremely rapidly, for example, when a child has a fever. Yet in around 50 percent of cases it is unclear as to why this happens. Now, a team of researchers working on an international research project headed by Technische Universität München (TUM), the Helmholtz Zentrum Munich and Heidelberg University Hospital have discovered a link between the disease and mutations in a specific gene. The…

Researchers identify new gene responsible for liver disease.

Acute liver failure is a rare yet life-threatening disease for young children. It often occurs extremely rapidly, for example, when a child has a fever. Yet in around 50 percent of cases it is unclear as to why this happens. Now, a team of researchers working on an international research project headed by Technische Universität München (TUM), the Helmholtz Zentrum Munich and Heidelberg University Hospital have discovered a link between the disease and mutations in a specific gene. The…

Zika virus may persist in eyes: Disease may spread from infected eyes

Zika virus may persist in eyes: Disease may spread from infected eyes

virus is capable of infecting the eye, according to a new study. The study, in mice, helps explain why some people with Zika virus develop eye disease, and suggests that contact with infected eyes may play a role in spreading the disease.

Researchers map epigenetic autism pathway during neurodevelopment.

Researchers map epigenetic autism pathway during neurodevelopment.

Spatiotemporal Protein Network Implicates Cortical Late Mid-Fetal Brain Development and Pathway in Psychiatric Diseases

By uncovering the mechanism by which fibrous tissue cells in the lung multiply, researchers at The Children's Hospital Los Angeles (CHLA), Keck School of Medicine, Nanjing Drum Tower Hospital, Instituto Nacional de Enfermedades Respiratorias, and McMaster University have identified a promising new approach for the treatment of pulmonary fibrosis. Idiopathic pulmonary fibrosis or IPF, where the disease appears spontaneously and without a known cause, is a severe, chronic lung disease in which…

Researchers map and control pulmonary fibrosis signalling pathway in preclinical trials.

By uncovering the mechanism by which fibrous tissue cells in the lung multiply, researchers at The Children's Hospital Los Angeles (CHLA), Keck School of Medicine, Nanjing Drum Tower Hospital, Instituto Nacional de Enfermedades Respiratorias, and McMaster University have identified a promising new approach for the treatment of pulmonary fibrosis. Idiopathic pulmonary fibrosis or IPF, where the disease appears spontaneously and without a known cause, is a severe, chronic lung disease in which…

Now, a new study from researchers at Sanford Burnham takes a step forward in understanding how similar, yet genetically unrelated neurodegenerative diseases, such as Alzheimer’s disease, frontal temporal dementia, and PSP are caused by the protein tau. The team states that their new study creates new opportunities to target this key protein that leads to the brain lesions found in patients with impaired motor functions and dementia. The opensource study is published in the journal Neuron.

Study identifies a previously unknown mechanism of neurofibrillary tangle formation.

Now, a new study from researchers at Sanford Burnham takes a step forward in understanding how similar, yet genetically unrelated neurodegenerative diseases, such as Alzheimer’s disease, frontal temporal dementia, and PSP are caused by the protein tau. The team states that their new study creates new opportunities to target this key protein that leads to the brain lesions found in patients with impaired motor functions and dementia. The opensource study is published in the journal Neuron.

In a group of patients diagnosed with colorectal cancer at 40 or younger, 1.3 percent of the patients carried germline TP53 gene mutations, although none of the patients met the clinical criteria for an inherited cancer syndrome associated with higher lifetime risks of multiple cancers, according to a study published by JAMA Oncology.

Researchers begin to map inherited gene mutations in colorectal cancer.

In a group of patients diagnosed with colorectal cancer at 40 or younger, 1.3 percent of the patients carried germline TP53 gene mutations, although none of the patients met the clinical criteria for an inherited cancer syndrome associated with higher lifetime risks of multiple cancers, according to a study published by JAMA Oncology.

Mutations linked to repair of chromosome ends may make emphysema more likely in smokers - healthinnovations

Epigenetic mutation which shortens telomeres linked to greater emphysema risk in smokers.

Mutations linked to repair of chromosome ends may make emphysema more likely in smokers - healthinnovations

Mutation of one gene is all it takes to get cystic fibrosis (CF), but disease severity depends on many other genes and proteins. For the first time, researchers at the UNC School of Medicine have identified genetic pathways,  or clusters of genes, that play major roles in why one person with CF might never experience the worse kinds of symptoms while another person will battle severe airway infection for a lifetime.  The finding opens avenues of research toward new precision medicine…

Researchers map epigenetic pathways linked to cystic fibrosis disease severity.

Mutation of one gene is all it takes to get cystic fibrosis (CF), but disease severity depends on many other genes and proteins. For the first time, researchers at the UNC School of Medicine have identified genetic pathways, or clusters of genes, that play major roles in why one person with CF might never experience the worse kinds of symptoms while another person will battle severe airway infection for a lifetime. The finding opens avenues of research toward new precision medicine…

Researchers discover new molecular-based immune response which protects lungs during severe infections.

Researchers discover new molecular-based immune response which protects lungs during severe infections.

Blood Vessels, Genetics, Lungs, Lunges

Genetic aspects of autism spectrum disorders: insights from anim

Precision medicine developed to protect against intellectual disability during neurodevelopment.

Genetic aspects of autism spectrum disorders: insights from anim

Study finds that blood vessel lining cells involved in the control of cancer metastasis.

Study finds that blood vessel lining cells involved in the control of cancer metastasis.

Blood Vessels, Surgery, Cancer, Therapy

Researchers discover new species of tRNA responsible for sex-biased cancer proliferation.

Researchers discover new species of tRNA responsible for sex-biased cancer proliferation.

Prostate Cancer, Breast Cancer, Protein, Thomas Jefferson, Genetics, 1950s, Templates, University, Led

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