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Metastatic HCC. Key findings are the presence of many naked nuclei, as demonstrated here, as well as trabecular growth with disordered balls of cells. Other suggestive features to look for include branching fine capillary proliferation, endothelial cell wrapping around "packeting", macronucleoli, and evidence of bile production by malignant-appearing cells.

Metastatic HCC. Key findings are the presence of many naked nuclei, as demonstrated here, as well as trabecular growth with disordered balls of cells. Other suggestive features to look for include branching fine capillary proliferation, endothelial cell wrapping around "packeting", macronucleoli, and evidence of bile production by malignant-appearing cells.

Pancreatic ductal adeno. Flat sheets of cells, three dimensional balls, and microacini
Columnar cells with delicate cytoplasm and polar nuclei (basal nuclei, apical cytoplsam)
Open chromatin with prominent central single nucleolus (versus squamous cell carcinoma with nuclei with dense chromatin and several small nucleoli, and dense cytoplasm)
Signet ring cells or intercellular glandular lumens

Pancreatic ductal adeno. Flat sheets of cells, three dimensional balls, and microacini Columnar cells with delicate cytoplasm and polar nuclei (basal nuclei, apical cytoplsam) Open chromatin with prominent central single nucleolus (versus squamous cell carcinoma with nuclei with dense chromatin and several small nucleoli, and dense cytoplasm) Signet ring cells or intercellular glandular lumens

Wilms tumor, 2 yo boy. This case is an excellent example of Nephroblastoma (Wilms' tumor). Although the other tumors listed as answer choices are pediatric renal tumors only Wilms' tumor would show triphasic morphology. In addition to cytomorphologic differences there are useful discriminating clinical features of the pediatric renal tumors:  Nephroblastoma (Wilms' tumor):    Most common pediatric renal tumor.  Usual age at diagnosis is 2-5 yrs and is uncommon in infants less than 6 months…

Wilms tumor, 2 yo boy. This case is an excellent example of Nephroblastoma (Wilms' tumor). Although the other tumors listed as answer choices are pediatric renal tumors only Wilms' tumor would show triphasic morphology. In addition to cytomorphologic differences there are useful discriminating clinical features of the pediatric renal tumors: Nephroblastoma (Wilms' tumor): Most common pediatric renal tumor. Usual age at diagnosis is 2-5 yrs and is uncommon in infants less than 6 months…

DFSP. was CD34 positive.

DFSP. was CD34 positive.

High grade urothelial carcinoma

High grade urothelial carcinoma

Atypical lymphoid proliferation which ended up being DLBCL

Atypical lymphoid proliferation which ended up being DLBCL

Elastofibroma. The aspirates are moderately cellular and show bland spindle cells with acellular collagen bundles and looser myxoid areas in the background. Additionally curious linear and globular structures were present on the Diff-Quik stained material (image 3).

Elastofibroma. The aspirates are moderately cellular and show bland spindle cells with acellular collagen bundles and looser myxoid areas in the background. Additionally curious linear and globular structures were present on the Diff-Quik stained material (image 3).

Metastatic adenocarcinoma to brain

Metastatic adenocarcinoma to brain

Synovial sarcoma. Bland and monomorphic, wrist of 11 year old boy

Synovial sarcoma. Bland and monomorphic, wrist of 11 year old boy

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