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What do you do if you have a headache, fever, or muscle pain? Chances are you go to the local drug store to pick up an over–the–counter (nonprescription) pain medicine. These drugs are the medicines most often used by Americans. Pain medicines, also called analgesics, help relieve pain, fever, and even inflammation. These medicines may help with arthritis, colds, headache (including migraine), muscle aches, menstrual cramps, sinusitis and toothache.These drugs are effective and usually safe. ...