"'The Hole in the Road' became part of Sheffield folklore from its construction in 1967 to its demolition in 1994. Its 27 year history saw it as memorable facet of the city for a variety of reasons that merged together in a loose fashion. As a 'residual jungle', the inclusion of a large and solitary fish tank was part of the allure of the underground structure."
Now, researchers from the University College Dublin and the University of Sheffield have identified a new gene, C5orf30, which encodes the 206-aa protein; which in turn regulates the severity of tissue damage caused by rheumatoid arthritis (RA). The team state that rheumatoid arthritis patients most likely to suffer the severest effects of the condition can now be identified early and fast-tracked to the more aggressive treatments available. The study is published in the journal PNAS.