Iconic tragedy of Indian Removal: the Cherokee Trail of Tears that relocated thousands of Cherokees to Indian Territory (now Oklahoma), was also a Black migration. Slaves of Cherokees walked this trail along with their Indian owners.
Signed into law by President Andrew Jackson on May the Indian Removal Act of 1830 act authorized the president to grant unsettled lands west of the Mississippi River in exchange for Indian lands within existing state borders.
Not-so-fun fact: Trump's favorite President killed more Americans during the Trail of Tears than Al Qaida did on 9/11. The Indian Removal Act was an act of genocide acknowledged as such the day it was signed.