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A leaky what? Simply put, abnormal intestinal permeability (aka Leaky Gut) arises when the tight junctions between these cells loosen, allowing for large, immune-confounding particles to be absorbed into the bloodstream. These can wreak havoc on many of the body’s tissues, including the liver, the thyroid, the skin, the joints, and the brain itself. #seasonalcleanse #farmacopia

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Role of flavonoids in intestinal tight junction regulation - Journal of Nutritional Biochemistry (Quercetin enhances intestinal tight junction barrier function.)

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Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor sign...

Zonulin's Role In Your Leaky Gut -What is Zonulin? Zonulin is a protein .. that opens the normally closed spaces between cells of the intestinal lining … (these) .. garage doors .. allow transfer of nutrients and other molecules from the intestine into the body when they are open … zonulin acts as the garage door opener ... When these tight junctions are left open, molecules that shouldn’t be absorbed are exposed to the blood which can cause the body’s immune system to react.

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Adherens and tight junctions: Structure, function and connections to the actin cytoskeletonFull-size image (10 K)

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

Bacteria find ways to enter the body through the lining of the gut, meeting the fighters of the immune system on the way ! Nature Immunology 2, 288 - 290 (2001)

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2