Zonulin's Role In Your Leaky Gut -What is Zonulin? Zonulin is a protein .. that opens the normally closed spaces between cells of the intestinal lining … (these) .. garage doors .. allow transfer of nutrients and other molecules from the intestine into the body when they are open … zonulin acts as the garage door opener ... When these tight junctions are left open, molecules that shouldn’t be absorbed are exposed to the blood which can cause the body’s immune system to react.
Research and leaders in the field of Hashimoto’s theorize that gluten is on many occasions part of the original causes of Hashimoto’s due to its molecular similarity with the Thyroid gland. Once the gluten molecules enter through the tight junctions in the gut and trigger an immune reaction, the immune system then looks through-out the body for other possible molecules which are similar – one of which is the Thyroid gland.