Message and tone are pretty spot on from the content to the coloring (or lack of). Only thing I dislike about this is the look of the "Smoking kills." I really think it could look a little better rather than just a white box with plain text.
I really like this poster. The shadow of the hand and cigarette appears to be a hand holding a gun. It would look even better with smoke coming out of the cigarette, making it look like the gun was just fired.
"Marlboro are the best you can buy. How can a girl like you afford these?" I look him dead in the eye "Darling, If I want to kill myself I'm going to do it in style. If you want to be the best you smoke the best.