Correlate with Pathophysiology! A 44 year old woman with worsening fatigue, tingling and numbness in bilateral lower extremities. Past Medical history of gastric bypass surgery and current use of dentures!
[MEGALOBLASTIC ANEMIA]. Coarse basophilic stippling is also a morphologic feature of MA but not specific to this disease and can be seen in other disorders including lead poisoning, sideroblastic anemia, thalassemia, certain hemoglobinopathies, and pyrimidine 5` nucleotidase deficiency. Defective DNA synthesis is also seen in congenital deficiency of certain enzymes including dihydrofolate reductase and methyltransferase.