Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM.  All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.

Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM. All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.

Pappenheimer vs. Howell-jolly body

Pappenheimer vs. Howell-jolly body

Ringed sideroblast sideroblastic anemia

Ringed sideroblast sideroblastic anemia

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Sideroblastic anemia

Sideroblastic anemia

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Ringed Sideroblasts Characteristic of Sideroblastic Anemia

Ringed Sideroblasts Characteristic of Sideroblastic Anemia

Coenzyme Q , sideroblastic anemia and mitochondrial myopathy Review Notes Dr. Mohammed AlKhateeb "Coenzyme Q10, also known as ubiquinone,ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10...

Coenzyme Q , sideroblastic anemia and mitochondrial myopathy Review Notes Dr. Mohammed AlKhateeb "Coenzyme Q10, also known as ubiquinone,ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10...

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A=Thalassemia Major B=Iron deficiency anemia C=Megaloblastic anemia D=Normocytic, normochromic anemia (hemolytic anemias, but Fe is elevated-->sideroblastic anemia should be suspected) E=Anemia of chronic disease

A=Thalassemia Major B=Iron deficiency anemia C=Megaloblastic anemia D=Normocytic, normochromic anemia (hemolytic anemias, but Fe is elevated-->sideroblastic anemia should be suspected) E=Anemia of chronic disease

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Sideroblastic anemia with ringed sideroblasts

Sideroblastic anemia with ringed sideroblasts

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