A ringed sideroblast must have 10 siderosomes surroundng at least one-third the nucleus.  Can be seen in ETOH, pyrazinamide, lead and benzene.

A ringed sideroblast must have 10 siderosomes surroundng at least one-third the nucleus. Can be seen in ETOH, pyrazinamide, lead and benzene.

Special Types Of Anemia: Sideroblastic Anemias And Paroxysmal Nocturnal Hemoglobinuria (PNH)

Special Types Of Anemia: Sideroblastic Anemias And Paroxysmal Nocturnal Hemoglobinuria (PNH)

Sideroblastic anemia - Causes, Diagnosis, Treatment, Ongoing care and Clinical pearls

Pappenheimer vs. Howell-jolly body

Pappenheimer vs. Howell-jolly body

Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM.  All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.

Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM. All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.

Pappenheimer Bodies = iron granules (sideroblastic anemia)

Pappenheimer Bodies = iron granules (sideroblastic anemia)

sideroblastic anemia = ringed sideroblasts in BM; low MCHC, bimodal RDW; iron indices all high (serum iron, transferrin, ferritin)

sideroblastic anemia = ringed sideroblasts in BM; low MCHC, bimodal RDW; iron indices all high (serum iron, transferrin, ferritin)

Ringed sideroblast sideroblastic anemia

Ringed sideroblast sideroblastic anemia

[MEGALOBLASTIC ANEMIA]. Coarse basophilic stippling is also a morphologic feature of MA but not specific to this disease and can be seen in other disorders including lead poisoning, sideroblastic anemia, thalassemia, certain hemoglobinopathies, and pyrimidine 5` nucleotidase deficiency. Defective DNA synthesis is also seen in congenital deficiency of certain enzymes including dihydrofolate reductase and methyltransferase.

[MEGALOBLASTIC ANEMIA]. Coarse basophilic stippling is also a morphologic feature of MA but not specific to this disease and can be seen in other disorders including lead poisoning, sideroblastic anemia, thalassemia, certain hemoglobinopathies, and pyrimidine 5` nucleotidase deficiency. Defective DNA synthesis is also seen in congenital deficiency of certain enzymes including dihydrofolate reductase and methyltransferase.

Iron Metobolism : When we eat iron, we generally get it in one of two forms: elemental iron or heme (from meat). In the intestine (proximal duodenum to be precise) the iron is either absorbed or actively transferred in. Iron is transported in the blood bound to transferrin and is stored in the liver bound to ferritin. This is why ferritin is measured when assessing iron stores.  Though most of the time you can make the diagnosis of iron deficiency anemia by assessing the patient’s history…

Iron Metobolism : When we eat iron, we generally get it in one of two forms: elemental iron or heme (from meat). In the intestine (proximal duodenum to be precise) the iron is either absorbed or actively transferred in. Iron is transported in the blood bound to transferrin and is stored in the liver bound to ferritin. This is why ferritin is measured when assessing iron stores. Though most of the time you can make the diagnosis of iron deficiency anemia by assessing the patient’s history…

Anemia can be an underlying symptom of an illness or a sign of a health problem. However, anemia is not a disease itself. If you are unsure if you have anemia, the best way to find out is to go to your doctor and get yourself checked out. There are types of anemia that are caused by the malfunctioning of the body, such as sideroblastic anemia, hemolytic anemia and sickle anemia. These types of anemia cannot be treated with these natural remedies. It requires proper diagnosis and…

Anemia can be an underlying symptom of an illness or a sign of a health problem. However, anemia is not a disease itself. If you are unsure if you have anemia, the best way to find out is to go to your doctor and get yourself checked out. There are types of anemia that are caused by the malfunctioning of the body, such as sideroblastic anemia, hemolytic anemia and sickle anemia. These types of anemia cannot be treated with these natural remedies. It requires proper diagnosis and…

Pappenheimer bodies = IRON granules in mitochondria = sideroblastic anemia and asplenism.

Pappenheimer bodies = IRON granules in mitochondria = sideroblastic anemia and asplenism.

Ring Sideroblasts in Sideroblastic Anemia. BM.

Ring Sideroblasts in Sideroblastic Anemia. BM.

Coenzyme Q , sideroblastic anemia and mitochondrial myopathy Review Notes Dr. Mohammed AlKhateeb "Coenzyme Q10, also known as ubiquinone,ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10...

Coenzyme Q , sideroblastic anemia and mitochondrial myopathy – Dr. Mohammed AlKhateeb

Coenzyme Q , sideroblastic anemia and mitochondrial myopathy Review Notes Dr. Mohammed AlKhateeb "Coenzyme Q10, also known as ubiquinone,ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10...

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