Receptor Tyrosine Kinase animation. Binding of insulin ligand will cause monomers to become dimers. Then, the (many) tyrosine(s) will auto-phosphorylate. This creates another conformational change that allows it to interact with an "adapter protein" which then indirectly binds with a G-protein. The tyrosine kinase can lead to multiple cellular responses from just ONE signal.
Receptor tyrosine kinases (RTK)s are very important signaling pathway, which not only include growth factor receptors such as EGFR(HER), VEGFR, PDGFR, FGFR, IGF-1R, Mast/stem cell growth factor receptor (c-Met) and HER2, but also other gene products which are expressed by the oncogenes such as SRC, Bcr, c-Met and Abl as well.