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Alterations in Resting State Functional Connectivity Link Mindfulness Meditation With Reduced Interleukin-6: A Randomized Controlled Trial - Biological Psychiatry

Two randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds.

Phase I: clinical pharmacologic studies that look at toxicity and pharmacologic effects. Phase II: clinical investigations of patients for efficacy and relative safety. Phase III: large-scale randomized controlled trials for effectiveness and relative safety, which are often multi-centrered. After a drug passes Phase III testing, it can be licensed for marketing. Phase IV (post-marketing surveillance): monitors new agents as they come into general use by the public.


JAMA Network | JAMA | Low-Dose Hydrocortisone for Treatment of Chronic Fatigue Syndrome:  A Randomized Controlled Trial

The Sertraline vs Electrical Current Therapy for Treating Depression Clinical Study Results From a Factorial, Randomized, Controlled Trial