Education: Big Conductance Potassium Channels.   So today we continue on the potassium channel journey and today we do the calcium activated potassium channels There are small conductance intermediate and big conductance calcium activated potssium channels called the SK channels and theBKchannels.  They are so called because of their small single channel conductance in the order of 10 pS(picoseimens = unit of electrical conductance The SK channel family contains 4 members -SK1SK2SK3 andSK4…

Education: Big Conductance Potassium Channels. So today we continue on the potassium channel journey and today we do the calcium activated potassium channels There are small conductance intermediate and big conductance calcium activated potssium channels called the SK channels and theBKchannels. They are so called because of their small single channel conductance in the order of 10 pS(picoseimens = unit of electrical conductance The SK channel family contains 4 members -SK1SK2SK3 andSK4…

Potassium overload and oligodendrocyte death   To continue on the theme that too much potassium is bad for oligodendrocyes and probably other cells http://ift.tt/2s6FrnR http://ift.tt/2s3xzEv Oligodendrocytes down regulate most of their potassium channels   However one channel reported to be of interest is the TASK-1 channel. This also known asPotassium channel subfamily K member 3 encoded by the KCNK3 (orK2P3.1) one of the members of the superfamily of potassium channel proteins containing…

Potassium overload and oligodendrocyte death To continue on the theme that too much potassium is bad for oligodendrocyes and probably other cells http://ift.tt/2s6FrnR http://ift.tt/2s3xzEv Oligodendrocytes down regulate most of their potassium channels However one channel reported to be of interest is the TASK-1 channel. This also known asPotassium channel subfamily K member 3 encoded by the KCNK3 (orK2P3.1) one of the members of the superfamily of potassium channel proteins containing…

EDUCATION: How does a nerve fire   When a nerve impulse is transmitted it moves because of the action of sodium channels. The outside of the cell is normally more electrically positive than the inside of the cell.  So when the stimulus comes along sodium ions which are electricialy positive start to move into the cell to make the inside of the cell more electrically positive and the outside more negative and it moves along at sodium channels (purple dots below). Then there is a reset. This…

EDUCATION: How does a nerve fire When a nerve impulse is transmitted it moves because of the action of sodium channels. The outside of the cell is normally more electrically positive than the inside of the cell. So when the stimulus comes along sodium ions which are electricialy positive start to move into the cell to make the inside of the cell more electrically positive and the outside more negative and it moves along at sodium channels (purple dots below). Then there is a reset. This…

Blocking potassium channels in immune cells to inhibit experimental disease.   Huang J Han S Sun Q Zhao Y Liu J Yuan X Mao W Peng B Liu W Yin J He X. Kv1.3 channel blocker (ImKTx88) maintains blood-brain barrier in experimental autoimmune encephalomyelitis. Cell Biosci. 2017 Jun 7;7:31. BACKGROUND:Disruption of blood-brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis…

Blocking potassium channels in immune cells to inhibit experimental disease. Huang J Han S Sun Q Zhao Y Liu J Yuan X Mao W Peng B Liu W Yin J He X. Kv1.3 channel blocker (ImKTx88) maintains blood-brain barrier in experimental autoimmune encephalomyelitis. Cell Biosci. 2017 Jun 7;7:31. BACKGROUND:Disruption of blood-brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis…

ndeed, potassium channel–modulating agents have demonstrated antitumor efficacy. Potassium channels regulate cancer cell behaviors such as proliferation and migration through both canonical ion permeation–dependent and noncanonical ion permeation–independent functions. Given their cell surface localization and well-known pharmacology, pharmacological strategies to target potassium channel could prove to be promising cancer therapeutics.

ndeed, potassium channel–modulating agents have demonstrated antitumor efficacy. Potassium channels regulate cancer cell behaviors such as proliferation and migration through both canonical ion permeation–dependent and noncanonical ion permeation–independent functions. Given their cell surface localization and well-known pharmacology, pharmacological strategies to target potassium channel could prove to be promising cancer therapeutics.

Changing the (potassium) channel? - Nature.com

Changing the (potassium) channel? - Nature.com

Wikipedia.org/***CELLS-- Potassium Channels-- are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Furthermore potassium channels are found in most cell types and control a wide variety of cell functions

Wikipedia.org/***CELLS-- Potassium Channels-- are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Furthermore potassium channels are found in most cell types and control a wide variety of cell functions

Mouse Anti-Slo2.2 Potassium Channel Antibody [S3-26] used in Immunohistochemistry (IHC) on Mouse backskin (SMC-323)

Mouse Anti-Slo2.2 Potassium Channel Antibody [S3-26] used in Immunohistochemistry (IHC) on Mouse backskin (SMC-323)

Mouse Anti-Slo2.1 Potassium Channel Antibody [S11-33] used in Immunohistochemistry (IHC) on Mouse backskin (SMC-324)

Mouse Anti-Slo2.1 Potassium Channel Antibody [S11-33] used in Immunohistochemistry (IHC) on Mouse backskin (SMC-324)

PDB-101: Potassium Channels

PDB-101: Potassium Channels

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