ndeed, potassium channel–modulating agents have demonstrated antitumor efficacy. Potassium channels regulate cancer cell behaviors such as proliferation and migration through both canonical ion permeation–dependent and noncanonical ion permeation–independent functions. Given their cell surface localization and well-known pharmacology, pharmacological strategies to target potassium channel could prove to be promising cancer therapeutics.

ndeed, potassium channel–modulating agents have demonstrated antitumor efficacy. Potassium channels regulate cancer cell behaviors such as proliferation and migration through both canonical ion permeation–dependent and noncanonical ion permeation–independent functions. Given their cell surface localization and well-known pharmacology, pharmacological strategies to target potassium channel could prove to be promising cancer therapeutics.

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This image shows a top view of potassium ions (purple) moving through potassium channel.

This image shows a top view of potassium ions (purple) moving through potassium channel.

Going native: voltage-gated potassium channels controlling neuronal excitability

Going native: voltage-gated potassium channels controlling neuronal excitability

Graph showing ventricular action potential with delayed repolarization by potassium channel blockade. K-channel blockers comprise the Class III antiarrhythmic compounds according to the Vaughan-Williams classification scheme. These drugs bind to and block the Kchannels that are responsible for phase 3 repolarization. Therefore, blocking these channels slows (delays) repolarization, which leads to an increase in action potential duration and an increase in the effective refractory period…

Graph showing ventricular action potential with delayed repolarization by potassium channel blockade. K-channel blockers comprise the Class III antiarrhythmic compounds according to the Vaughan-Williams classification scheme. These drugs bind to and block the Kchannels that are responsible for phase 3 repolarization. Therefore, blocking these channels slows (delays) repolarization, which leads to an increase in action potential duration and an increase in the effective refractory period…

Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation

Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation

Torsade de pointes. This is a polymorphic ventricular tachycardia (VT) associated with resting QT-interval prolongation. In this case, it was caused by the potassium channel blocker, sotalol. This rhythm is also observed in families with mutations affecting certain cardiac ion channel

Torsade de pointes. This is a polymorphic ventricular tachycardia (VT) associated with resting QT-interval prolongation. In this case, it was caused by the potassium channel blocker, sotalol. This rhythm is also observed in families with mutations affecting certain cardiac ion channel

Potassium channels contribute to primary activation of the VNO. Courtesy of Ron Yu, Stowers Institute.

Potassium channels contribute to primary activation of the VNO. Courtesy of Ron Yu, Stowers Institute.

Structural images shed new light on a cancer-linked potassium channel http://www.sciencetotal.com/news/2016-08-structural-images-shed-new-light-on-a-cancer-linked-potassium-channel/

Structural images shed new light on a cancer-linked potassium channel http://www.sciencetotal.com/news/2016-08-structural-images-shed-new-light-on-a-cancer-linked-potassium-channel/

Structural Determinants of Specific Lipid Binding to Potassium Channels

Structural Determinants of Specific Lipid Binding to Potassium Channels

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