Inhibition of p-glycoprotein by quinidine increasing concentration of digoxin

Inhibition of p-glycoprotein by quinidine increasing concentration of digoxin

Strategy Developed to Improve Delivery of Medicines to the Brain - The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

Strategy Developed to Improve Delivery of Medicines to the Brain - The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

Simplified efflux mechanism of P-gp substrate

Simplified efflux mechanism of P-gp substrate

Imaging B cells   James ML Hoehne A Mayer AT Lechtenberg K Moreno M Gowrishankar G Ilovich O Natarajan A Johnson EM Nguyen J Quach L Han M Buckwalter M Chandra S Gambhir SS. Imaging B cells in a mouse model of multiple sclerosis using 64Cu-Rituximab-PET. J Nucl Med. 2017 Jul 7. pii: jnumed.117.189597. doi: 10.2967/jnumed.117.189597. [Epub ahead of print] B lymphocytes are a key pathological feature of multiple sclerosis (MS) and are becoming an important therapeutic target for this…

Imaging B cells James ML Hoehne A Mayer AT Lechtenberg K Moreno M Gowrishankar G Ilovich O Natarajan A Johnson EM Nguyen J Quach L Han M Buckwalter M Chandra S Gambhir SS. Imaging B cells in a mouse model of multiple sclerosis using 64Cu-Rituximab-PET. J Nucl Med. 2017 Jul 7. pii: jnumed.117.189597. doi: 10.2967/jnumed.117.189597. [Epub ahead of print] B lymphocytes are a key pathological feature of multiple sclerosis (MS) and are becoming an important therapeutic target for this…

Figure 3: Unhealthy diets such as high fat diets downregulate hepatic drug metabolism with the corruption of insulin therapy in diabetes and aging. Amyloid beta metabolism in the brain and liver are connected to drug metabolism and defective hepatic drug metabolism may be the primary defect in Type 3 diabetes with acceleration of neuronal apoptosis by abnormal brain amyloid beta metabolism associated with Type 1 or Type 2 diabetes. Abbreviations: P-gp1, P glycoprotein, PXR, pregnane X…

Figure 3: Unhealthy diets such as high fat diets downregulate hepatic drug metabolism with the corruption of insulin therapy in diabetes and aging. Amyloid beta metabolism in the brain and liver are connected to drug metabolism and defective hepatic drug metabolism may be the primary defect in Type 3 diabetes with acceleration of neuronal apoptosis by abnormal brain amyloid beta metabolism associated with Type 1 or Type 2 diabetes. Abbreviations: P-gp1, P glycoprotein, PXR, pregnane X…

Multidrug ABC transporter, P-glycoprotein (with sound)

Multidrug ABC transporter, P-glycoprotein (with sound)

Antibodies and their antigen. Computer model showing the molecular structure of two anti-P-glycoprotein antibodies (upper left and right) and the P-glycoprotein (blue) to which they respond. These antibodies will bind to the glycoprotein, preventing it from functioning.  ©Laguna Design/Science Source

SP8395: Antibodies and their antigen

Antibodies and their antigen. Computer model showing the molecular structure of two anti-P-glycoprotein antibodies (upper left and right) and the P-glycoprotein (blue) to which they respond. These antibodies will bind to the glycoprotein, preventing it from functioning. ©Laguna Design/Science Source

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

P-Glycoprotein

P-Glycoprotein

Toxicology of Avermectins and Milbemycins (Macrocylic Lactones) and the Role of P-Glycoprotein in Dogs and Cats

Toxicology of Avermectins and Milbemycins (Macrocylic Lactones) and the Role of P-Glycoprotein in Dogs and Cats

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