Making MS worse more evidence for a T cell origin Lisa Ann Gerdes Kathrin Held Eduardo Beltrán Carola Berking Jörg C. Prinz Andreas Junker Julia K. Tietze Birgit Ertl-Wagner Andreas Straube Tania Kümpfel Klaus Dornmair and Reinhard HohlfeldCTLA4 as Immunological Checkpoint in the Development of Multiple SclerosisAnals Neurol2016 | DOI: 10.1002/ana.24715 We investigated a patient who developed multiple sclerosis (MS) during treatment with the CTLA4-blocking antibody ipilimumab for…
Wind-up pain is caused by activation of normally dormant NMDA receptors.Activated NMDA receptors cause - influx of Calcium into Dorsal Horn Wide Dynamic Range interneurons resulting in a cycle of - increased production/sensitization/number of NMDA receptors & increased release of Glutamate/Substance-P at presynaptic sites This positive feedback loop results in a marked increase in the pain signal ultimately perceived by the brain.
Gathering the clues to rare gene variants contributing to schizophrenia February 21st Schizophrenia has long been known to be highly heritable and is present in approximately 1% of the population. Researchers have been following two paths in their pursuit of identifying schizophrenia risk genes. - See more at: http://allblackclothes.com/index.php?cID=159#sthash.YJBzfCQA.dpuf
NMDA (N-methyl-D-aspartate) is the selective agonist that binds to NMDA receptors but not to other glutamate receptors. The NMDA receptor (NMDAR) is the predominant molecular device for controlling synaptic plasticity and memory function. The NMDAR is a type of ionotropic glutamate receptor. Activation of NMDA receptors requires binding of glutamate or aspartate (aspartate does not stimulate the receptors as strongly). In addition, NMDARs also require the binding of the co-agonist glycine.
A new pharmaceutical technology licensed in February by the Corporate Ventures office at The Hospital for Sick Children (SickKids) may help treat neuropathic and inflammatory pain in children and adults, but without the serious side effects that can accompany currently available treatments.
CHILDREN with Anti NMDA Receptor Encephalitis - This is the best VIDEO that shows what the experience is like for a child. It is very different from that of an adult. From CTV news - Mystery illness often misdiagnosed in kids: Anti NMDA Receptor Autoimmune Encephalitis