There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in primates like humans. However, adolescent cynomolgus monkeys that were injected daily for six months with the non-competitive NMDA antagonist ketamine showed decreased locomotor activity and increased apoptosis of cells in their prefrontal cortices.

There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in primates like humans. However, adolescent cynomolgus monkeys that were injected daily for six months with the non-competitive NMDA antagonist ketamine showed decreased locomotor activity and increased apoptosis of cells in their prefrontal cortices.

Stopping anti-clotting medications in some patients with irregular heartbeats may raise the risk of stroke or blood clotting within a month, finds a new research.

Stopping anti-clotting medications in some patients with irregular heartbeats may raise the risk of stroke or blood clotting within a month, finds a new research.

DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative…

DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative…

Biochemistry of Memantine:   The drug belongs to a class of drugs called NMDA receptor antagonists, which reduce certain types of brain activity by binding to NMDA receptors on brain cells and blocking the activity of the neurotransmitter glutamate. At normal levels, glutamate aids in memory and learning, but if levels are too high, glutamate appears to overstimulate nerve cells, killing them through excitotoxicity.

Biochemistry of Memantine: The drug belongs to a class of drugs called NMDA receptor antagonists, which reduce certain types of brain activity by binding to NMDA receptors on brain cells and blocking the activity of the neurotransmitter glutamate. At normal levels, glutamate aids in memory and learning, but if levels are too high, glutamate appears to overstimulate nerve cells, killing them through excitotoxicity.

NMDA receptor antagonist ... Can be used to treat resistant forms of Catatonia

NMDA receptor antagonist ... Can be used to treat resistant forms of Catatonia

Alomone Labs D-AP5, a competitive NMDA receptor antagonist.

Alomone Labs D-AP5, a competitive NMDA receptor antagonist.

Ketamine Is….. an NMDA receptor antagonist that is usually used in anesthesia in humans and animals.  Often  delivered as an infusion or intramuscularly, or as a cream or gel (often in combination with other analgesics), Ketamine is effective, at least in the short term, in treating several chronic pain states …

Ketamine Is….. an NMDA receptor antagonist that is usually used in anesthesia in humans and animals. Often delivered as an infusion or intramuscularly, or as a cream or gel (often in combination with other analgesics), Ketamine is effective, at least in the short term, in treating several chronic pain states …

Phencyclidine (a complex clip of the chemical name 1-(1-phenylcyclohexyl)piperidine), (PCP) and known colloquially as angel dust or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits both hallucinogenic and neurotoxic effects. PCP is an NMDA receptor antagonist.PCP is an NMDA receptor antagonist. PCP, like ketamine, also acts as a D2 receptor partial agonist. D2 receptor antagonists (such as haloperidol) can be used in the treatment of PCP psychosis.

Phencyclidine (a complex clip of the chemical name 1-(1-phenylcyclohexyl)piperidine), (PCP) and known colloquially as angel dust or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits both hallucinogenic and neurotoxic effects. PCP is an NMDA receptor antagonist.PCP is an NMDA receptor antagonist. PCP, like ketamine, also acts as a D2 receptor partial agonist. D2 receptor antagonists (such as haloperidol) can be used in the treatment of PCP psychosis.

Memantine is approved for the treatment of moderate to severe  Alzheimer’s. It is an N-methyl-D-aspartate (NMDA) receptor antagonist.  The NMDA receptor is one of several receptors located on  the postsynaptic neurons in the hippocampus, which receive  transmissions from the neurotransmitter glutamate. Glutamate is a major excitatory neurotransmitter that is associated  with learning and memory, used by more than 80% of the neurons  in the brain.

Memantine is approved for the treatment of moderate to severe Alzheimer’s. It is an N-methyl-D-aspartate (NMDA) receptor antagonist. The NMDA receptor is one of several receptors located on the postsynaptic neurons in the hippocampus, which receive transmissions from the neurotransmitter glutamate. Glutamate is a major excitatory neurotransmitter that is associated with learning and memory, used by more than 80% of the neurons in the brain.

Pinterest • The world’s catalogue of ideas
Search