What Triggers Your Sensory Overload? Many people with multiple sclerosis (MS) have symptoms that aren’t talked about very much. One of these is sensory overload. When surrounded by too much noise, exposed to too many visual stimuli, or put in new or loud environments, many people with MS report experiencing confusion, fatigue, and pain. Sometimes, sensory overload is related to myoclonus, a stimulus-sensitive symptom that can cause involuntary jerking of muscles.