One of the most well known Yankees this is Lou Gehrig. He made his debut to the MLB on the Yankees in 1923, and his last appearance was also on the Yankees in 1939. He was nicknamed "The Iron Horse". His batting average was .340. He was voted the best 1st baseman of all time. He died of Amyotrophic lateral sclerosis or "Lou Gehrigs Disease.
Amyotrophic lateral sclerosis (ALS) often referred to as Lou Gehrig's Disease. "Every 90 minutes, someone is diagnosed with ALS and every 90 minutes someone dies from ALS. It has been over 140 years since the disease was first diagnosed and we still have no cure, no viable treatment, and no known cause." ALS is 100% fatal.