Lepirudin is an anticoagulant that functions as a direct thrombin inhibitor. Brand name: Refludan, Generic: Lepirudin rDNA for injection. Lepirudin is a recombinant hirudin derived from yeast cells. It is almost identical to hirudin extracted from Hirudo medicinalis.Lepirudin may be used as an anticoagulant when heparins (unfractionated or low-molecular-weight) are contraindicated because of heparin-induced thrombocytopenia.
Heparin induced thrombocytopenia. Antibody forms to heparin-PF4 complex that sits on surface of platelet. IgG antibodies. Usually about 10 days after heparin starts. Gold standard is Serotonin Release Assay but can also just detect the antibodies (IgG by far most common and significant) and then see if adding extra heparin quenches them (you should get a negative or much more decreased result after adding excess heparin)
Attributable Healthcare Cost and Length of Hospital Stay Associated with Heparin-Induced #Thrombocytopenia For Complete Research Paper: http://www.annexpublishers.com/full-text/JHBD/1105/Attributable-Healthcare-Cost-and-Length-of-Hospital-Stay-Associated-with-Heparin-Induced-Thrombocytopenia.php
Heparin-Induced Thrombocytopenia: the reason why it is not recommended for use beyond 48 hrs. Other options besides UFH and LMWH (i. HIT assay to confirm and switch to argatroban for anticoagulant needs.