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Topic: Glutamate and NMDA receptors..."exciting", but technical

Glutamate and GABA Balance

Glutamate and GABA Balance | Chronic Disease Recovery


Scientists discover the 'missing link' that triggers Alzheimer’s - and hope findings could lead to drugs that restore memory

Researchers at Yale University have found that blocking a protein called 'metabotropic glutamate receptor could restore memory and learning in the brain.

Mothers with diabetes more likely to have autism-linked anti-fetal brain autoantibodies.

Please welcome powerhouse author Bernice L. McFadden to Writer Unboxed today! Bernice is the author of nine critically acclaimed novels including Sugar, Loving Donovan, Nowhere Is a Place, The Warm…

Cholinesterase inhibitors work by reducing the breakdown of acetylcholine in the brain, a chemical which helps neurons to communicate.Memantine preferentially blocks excessive extrasynaptic activity of the N-methyl-D-aspartate (NMDA) glutamate receptors i

"Monosodium glutamate (MSG) is a widely used flavor enhancer. It is said to add a 5th flavor to foods, a savoury taste, adding onto the four basic tastes (salt, sweet, sour and bitter). It has many names, ranging from accent and vetsin to ajinomoto. What is so curious about MSG is that it does not act by adding a specific taste of its own (as does salt or sugar), but instead it seems to serve as a stimulant which increases the sensitivity of taste receptors thus "multiplying" the taste of…


'The steady decline in risky choices with age matches a steady decline in dopamine levels. Throughout adult life, dopamine levels fall by up to 10% every decade. Dopamine is a chemical in the brain involved in predicting which actions will lead to rewards, and the researchers previously found that volunteers chose significantly more risky gambles to win more money when given a drug that boosted dopamine levels.' Declining dopamine may explain why older people take fewer risks:

What a difference a few weeks make Tale of two trials Animal studies get rubbished all the time and one thing that gets peoples backs up is the failure to translate. It is sad when this happens because of the wasted effort and the dashed hopes. As soon as a trial fails however the community view is often very blinkered and it gets the idea that this or that drug is no good and the mud sticks. Therefore animal studies take another bashing. However we do not do enough "trial bashing". I…

Study identifies microtubule protein crucial for synaptic plasticity and memory.

Protein Crucial,Synaptic Plasticity,Study Identifies,Glutamate,Receptors,Memory,Fitness


The Cellular Scale: Ketamine for depression via neurogenesis? The idea is that ketamine blocks the NMDA receptors on the GABAergic (inhibitory) neurons, so there is less inhibition and more glutamate. When there is more glutamate, there is more BDNF (brain derived neurotrophic factor). BDNF helps synapsse grow by triggering a cascade of events (via mTOR) which causes more AMPA receptors to be inserted into the synapse, making the synapse stronger, more stable, and more mature.