Plant Neurobiology Sprouts Anew | The Scientist Magazine®. About systems of communication within plants similar to neural transmission in animals. Maybe not so surprising given that animals and plants co-evolved. Concepts such as glutamate receptors and neurotransmitters in both animals and plants are very intriguing.
Wind-up pain is caused by activation of normally dormant NMDA receptors.Activated NMDA receptors cause - influx of Calcium into Dorsal Horn Wide Dynamic Range interneurons resulting in a cycle of - increased production/sensitization/number of NMDA receptors & increased release of Glutamate/Substance-P at presynaptic sites This positive feedback loop results in a marked increase in the pain signal ultimately perceived by the brain.