Figure 2: Subtypes of muscarinic and nicotinic receptors - the peripheral nicotinic receptors at the neuromuscular junction are of the N1 or Nm type and the central nicotinic receptors are of the neuronal nicotinic acetylcholinesterase subtype (Nn or N2). All five (M1 to M5) muscarinic receptor subunits are present in the central nervous system. The peripheral muscarinic receptors are predominantly of the M3 subunit although the M2 subunit is also represented in the heart and exocrine glands
Massage can play an important role in helping to manage the symptoms of many chronic illnesses. Individuals with Sjorgens Syndrome may benefit from using facial massage as it stimulates the exocrine glands of the face -- the Parotid, Submandibular, Sublingual, and Lacrimal glands.