U.S. Food and Drug Administration approved ribociclib (KISQALI®, Novartis Pharmaceuticals Corp.), a cyclin-dependent kinase 4/6 inhibitor, in combination with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer.
#Chemo Week 130: We found out this morning that my mom's monthly chemo infusions are indefinite Because she's Stage IV (metastatic) and was HER2 positive (human epidermal growth factor receptor 2) this course of continued treatment is necessary to keep her healthy. We were expecting her to be done with 'the drip' this year having to only take an oral chemo for the next four years. As much as my mom likes her chemo buddies at Southwest I'm sure she'd be happy to never have to make another…
Epidermal Growth Factor Receptor and Its Applications - The discovery of growth factors won the Nobel Prize in Medicine in 1986, implying their importance. Epidermal growth factor receptor, EGFR, one of such factors, exists on cell surface and is activated by binding of its specific ligands. EGFR is a member of the receptor tyrosine kinase family whose members play a critical role in oncogenesis. Mutations affecting EGFR expression or activity could result in cancers, ...
EGF (Epidermal Growth Factor) is a small 53 amino acid residue protein that is involved in normal cell growth, oncogenesis, and wound healing. This protein shows both strong sequential and functional homology with hTGF-Alpha (human type-Alpha Transforming Growth Factor), which is a competitor for EGF receptor sites. EGF binds to a specific high-affinity, low-capacity receptor on the surface of responsive cells known as EGFR (Epidermal growth factor receptor).
Human epidermal growth factor receptor 2 (HER2)–positive breast cancer has been recognized as a distinct subtype since the early 1980s when researchers discovered a link between high levels of HER2 and the ability of cancer cells to grow rapidly (Kumar & Badve, 2008).
Chemotherapy and Targeted Therapy for Women With Human Epidermal Growth Factor Receptor 2–Negative (or unknown) Advanced Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline: Journal of Clinical Oncology: Vol 32, No 29
FDA Approves Marketing Ipsogen JAK2 RGQ PCR Kit to Help Evaluate Suspected Polycythemia Vera
Human 'Atlas' Reveals Where Proteins Reside in the Body
An image of a protein called EGFR (epidermal growth factor receptor) in human cells viewed under a microscope. EGFR, which is shown in green, is localized to the cell's membrane. The cell's nucleus is shown in blue.