David Bowie has a condition called anisocoria, which is the medical term for unequal pupils. At age 14 he got punched in the eye during a fight. David was admitted to Farnborough Hospital, where it was found that the sphincter muscles of his left eye were badly torn and he underwent two eye operations. He has an enlarged pupil that remains permanently open, giving them an unusual appearance.
The Story Behind David Bowie’s Unusual Eyes: His eyes were the product not of genes but a teenage fistfight that resulted in anisocoria, a condition in which a person’s eyes have different-size pupils.
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David Bowie has two different colored eyes, which typically is caused by heterochromia iridum. However, he does not have two different colored irises. In 1962, Bowie was in a fight which left him with a permanently dilated pupil, which causes his left eye to appear to be a different color.