Gene Duplication: most important source of new genes; can result from unequal crossing-over: a chance mistake caused by the proteins involved in managing recombination during meiosis; homologous chromosomes don't synapse correctly during prophase of meiosis I & results in a chromosome with a redundant stretch of DNA; has an extra copy; because 1 copy produces normal product, the other is free to accumulate mutations w/o consequences to phenotype; might change function to become new gene

Gene Duplication: most important source of new genes; can result from unequal crossing-over: a chance mistake caused by the proteins involved in managing recombination during meiosis; homologous chromosomes don't synapse correctly during prophase of meiosis I & results in a chromosome with a redundant stretch of DNA; has an extra copy; because 1 copy produces normal product, the other is free to accumulate mutations w/o consequences to phenotype; might change function to become new gene

Genetics in Medicine - Abstract of article: Copy number variations associated with autism spectrum disorders contribute to a spectrum of neurodevelopmental disorders

Genetics in Medicine - Abstract of article: Copy number variations associated with autism spectrum disorders contribute to a spectrum of neurodevelopmental disorders

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Signature of backward replication slippage at the copy number variation junction

Signature of backward replication slippage at the copy number variation junction

SNP and copy number variation Databases

SNP and copy number variation Databases

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CD Genomics provides a number of options for those looking to perform copy number variation (CNV) analysis on several different microarray platforms depending on the organism, starting material and size of your project. http://www.cd-genomics.com/CNV-Analysis-Service.html

CD Genomics provides a number of options for those looking to perform copy number variation (CNV) analysis on several different microarray platforms depending on the organism, starting material and size of your project. http://www.cd-genomics.com/CNV-Analysis-Service.html

8p23.1 duplication syndrome differentiated from copy number variation of the defensin cluster at prenatal diagnosis in four new families

8p23.1 duplication syndrome differentiated from copy number variation of the defensin cluster at prenatal diagnosis in four new families

Mitochondrial DNA copy number variation across human cancers

Mitochondrial DNA copy number variation across human cancers

A numbers game – Copy Number Variations in schizophrenia

A numbers game – Copy Number Variations in schizophrenia

RCCX Copy Number Variation Traced by Haplotypes of the CYP21A2 Gene

RCCX Copy Number Variation Traced by Haplotypes of the CYP21A2 Gene

Integrated small copy number variations and epigenome maps of disorders of sex development

Integrated small copy number variations and epigenome maps of disorders of sex development

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