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from ScienceDaily

Nanoscale building blocks and DNA 'glue' help shape 3D architectures

Scientists devised a new way of assembling ordered crystals made of nanoparticles. In this process, nanoparticles in the shape of cubes, octahedrons, and spheres coordinate with each other to build structures. The shapes are bound together by complementary DNA molecules on each type of particle.

During DNA replication, each strand of the original molecule acts as a template for the synthesis of a new, complementary DNA strand.

In Situ Hybridization (ISH) In Situ Hybridization (ISH) refers to localizing a specific DNA or RNA sequence in whole embryos or tissues/tissue sections/cells using a labeled probe. The probe is either a labeled complementary DNA (oligoprobe) or a complementary RNA (riboprobe)....

Transcription proceeds in the following general steps: One or more sigma factor protein binds to the RNA polymerase holoenzyme, allowing it to bind to promoter DNA. RNA polymerase creates a transcription bubble, which separates the two strands of the DNA helix. This is done by breaking the hydrogen bonds between complementary DNA nucleotides. RNA polymerase adds matching RNA nucleotides to the complementary nucleotides of one DNA strand.

Controlling the self-assembly of nanoparticles into superlattices is an important approach to build functional materials. The Brookhaven team used nanosized building blocks—cubes or octahedrons—decorated with DNA tethers to coordinate the assembly of spherical nanoparticles coated with complementary DNA strands.