Lyme Disease Bacteria from a tick bite also cause this. It can bring on fever, chills, tiredness, body aches, and a headache. Another sign is a “bull’s-eye” rash that’s clear in the middle and grows over a period of days -- it can be up to 12 inches across. The rashes -- there can be more than one -- don't necessarily show up near the bite. Lyme disease is treated with antibiotics, but some people still have aches and tiredness after finishing the drugs.