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BRAF: From Gene to Cancer Therapy

Look at real cancer DNA datasets (from cancer patients) to find areas of mutation in the BRAF gene [yourgenome.org]

A BRAF gene mutation in melanoma patients has been found to respond to MEK inhibitor drugs, providing a reason for routine screening and therapy in melanoma patients with the BRAF L597 mutation.

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BRAF Gene Mutations Are Rare Events in Gastroenteropancreatic Neuroendocrine Tumors - Click on Image

Colorectal carcinoma is the most frequent type of bowel cancer and the second most common tumour disease among men and women in Germany. So-called microsatellite stable colorectal cancer with mutations in the BRAF gene represents a particularly aggressive form. The BRAF gene produces the enzyme B-Raf, ...

Drug-Resistant Melanoma Treatment May Be Enhanced: Study - More than 8,000 Americans are killed each year by melanoma — the deadliest form of skin cancer. The presence of mutations in a gene known as the BRAF gene drives approximately 40 percent of advanced melanoma tumors. | RedOrbit/Nov 2013

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BRAF DISCOVERY - We helped fund the ground breaking study that identified faults in the BRAF gene as a key cause of malignant melanoma. This led to the development of the drug vemurafenib. Read the full story here: http://scienceblog.cancerresearchuk.org/2009/08/24/high-impact-science-%E2%80%93-finding-faults-in-braf/#

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Targeted Tx Slows Melanoma Progress

A new drug that targets mutated BRAF in metastatic #melanoma showed greater progression-free survival (PFS) compared with conventional chemotherapy, an open-label phase III trial found.

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About half of all advanced melanomas have a defect in the BRAF gene. A new strategy may extend the survival time of people living with the most serious form of skin cancer.