Wikipedia.org/***DRUG-- Gabapentin Enacarbil-- (Horizant (in USA), Regnite (in Japan), formerly known as XP-13512) is a prodrug for the anticonvulsant and analgesic drug gabapentin. It was designed for increased oral bioavailability over gabapentin, and human trials showed it to produce extended release of gabapentin with almost twice the overall bioavailability, especially when taken with a fatty meal
Ohmefentanyl (β-hydroxy-3-methylfentanyl) was discovered in 1995 and is an extremely potent analgesic drug which selectively binds to the µ-opioid receptor. Ohmefentanyl is one of the most potent μ -receptor agonists known, comparable to super-potent opioids such as carfentanil and etorphine
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Clinical Psychiatry News (3/13) has the story. West Virginia Senator Joe Manchin is protesting FDA approval of the drug. He’s written a stunning letter to US Health and Human Services head, Kathleen Sebelius. “…Sen. Manchin noted that the FDA approved the drug ‘despite strong opposition from its own Anesthetic and Analgesic Drug Products Advisory Committee.’”