5 ways to cook with wine | The majority of alcohol in wine burns off during the cooking process. The amount that remains in the dish depends on the cooking method and amount of cooking time. A quick flambé may not burn off all the alcohol, whereas a wine reduction sauce will leave very little, if any, alcohol content. Heat and time are key. For instance, slow-cooking a stew for two and a half hours will leave just 5% of the alcohol, while 20 minutes will leave 40%.