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Biotin Figure 2. Acetyl-CoA Carboxylase 1 and Acetyl-CoA Carboxylase 2. In the cytosol of liver cells, fatty acids are converted to acyl-CoA, and glucose undergoes glycolysis that produces pyruvate. Acyl-CoA is shuttled into the mitochondria via CPT1-mediated transport and undergoes β-oxidation that generates acetyl-CoA. In addition, pyruvate is converted to acetyl-CoA in the mitochondria, and acetyl-CoA is condensed with oxaloacetate to form citrate. The latter can be exported to the…

TJ. Glycolysis breaks glucose (a six-carbon-molecule) down into pyruvate (a three-carbon molecule). In eukaryotes, pyruvate moves into the mitochondria. It is converted into acetyl-CoA by decarboxylation and enters the citric acid cycle.


Acetyl-CoA CoEnzyme A Precursor | Energy Supplement - Swanson Health Products

Oxidative Decarboxylation of pyruvate: in mitochondria; pyruvate formed during glycolysis is transported from cytoplasm into mitochondrial matrix where it is decarboxylated (loses a CO2) & the acetyl group that remains is transferred to coenzyme A to form acetyl CoA; in the process, NAD+ is reduced to NADH